Postdoctoral Researcher, siRNA and CRISPR Platforms

Alloy Therapeutics, Inc. • Full-time • Waltham, MA, US • 1d ago

The Company

We are Alloy Therapeutics—a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.

Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions.We strive to have workers in the office when needed to interact organically and face-to-face.Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year.We respect and value our colleagues for their hard work that requires them to be in the lab every day.We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility.We are all one team!

The Team

The Alloy Genetic Medicines group is innovating a novel RNA-based drug discovery platform, namely “AntiClastic”, spanning the fields of antisense therapeutics to immunomodulating therapeutics. This technology platform was launched by Alloy in 2023 after exclusively licensing its underlying intellectual property which implements a novel spatial conformation of the oligonucleotide developed by Sudhir Agrawal of Arnay Sciences. The team works closely with external partners to discover and develop AntiClastic RNA medicines.

The Role

Alloy’s Genetic Medicine group is seeking multiple motivated postdoctoral Researchers to join its team in Waltham, MA. The postdoc positions are open to candidates who have recently graduated and whose research topic has been in the siRNA or CRISPR/Editing fields and could have one year of postdoctoral experience. Our research involves experiments with RNA biology, Oligonucleotide chemistry, Antisense and siRNA designs, Gene editing and mRNA Therapeutics.

How You’ll Drive Impact

Improve: Learn and identify key questions in the RNA medicine area
Innovate: Advance the platform for RNAi and gene editing applications
Deliver: Design, execute, analyze, and interpret in vitro and in vivo experiments
Collaborate: Work closely with other members of the team to ensure studies are executed to meet scientific goals

Principal Responsibilities

Work with the scientific leaders in the group to advance the platform to RNAi and Editing modalities
Design and conduct in vitro and in vivo studies to evaluate efficacy, PK/PD relationship with the goal of developing and optimizing the platform
Design and execute several molecular biology techniques including, but not limited to, nucleic acid isolation, RT-qPCR, western blots and ELISA
Analyze data using GraphPad software and prepare presentation-ready images to effectively communicate experimental findings
Maintain comprehensive and accurate records of all experiments using the Benchling electronic notebook, ensuring meticulous documentation and data integrity
Present data in scientific conferences and publish manuscripts in high-impact peer reviewed journals

Qualifications

A background in RNA Biology and a recent graduate with a PhD in Biochemistry, Molecular Biology or related field
Collaborative and self-motivated team player
Effective interpersonal skills, including both written and oral communication skill
Experience in oligonucleotide modalities (siRNA/Editing) is highly desirable

Taking Care of Our People

We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.

Compensation

Competitive base and equity compensation commensurate with level of experience and independence
401(k) company match

Health & Family

Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
Company-paid disability (STD, LTD) and life insurance
Paid parental leave
Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)

Unique Perks

Unlimited PTO (paid time off) and flexible schedules
Annual stipend for continuing education with commitment to your career through individualized professional development plan
Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness

Pay Transparency

At Alloy Therapeutics, we believe in fostering trust and open communication. For this role, the estimated annual base salary range is $65,000 - $80,000, with the final offer based on factors like your experience, skills, and alignment with our needs.

Additionally, this role is eligible for equity compensation, reflecting our commitment to shared success as we work together to make better medicines.

We are proud to offer competitive compensation and benefits, aiming to support our team’s professional and personal well-being. If you have any questions about pay or benefits, we’re here to help.

Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at recruiting@alloytx.com. We will make every effort to respond to your request for disability assistance as soon as possible.

Powered by JazzHR

orLz0lFfom