Project Overview:

Fibrosis, characterized by excessive extracellular matrix (ECM) deposition, leads to tissue scarring and

organ dysfunction. In the ovary, age-associated fibrosis contributes to reduced fertility, but the underlying

mechanisms remain poorly understood. This project aims to investigate the role of ovulation frequency

and immune cells in ovarian fibrosis, with the long-term goal of enhancing female reproductive health

and longevity. Using a multidisciplinary approach, the research will explore cellular and molecular

pathways, including fibroblast activation, immune cell modulation, and ligand-receptor interactions, to

identify potential therapeutic targets.

Responsibilities:

• Design and conduct experiments using murine models, including surgeries, single-cell RNA

sequencing (scRNA-seq), and molecular biology techniques.

• Analyze and interpret data to uncover cellular and molecular mechanisms underlying ovarian

fibrosis.

• Collaborate with a multidisciplinary team to integrate findings and develop novel hypotheses.

• Present research findings at conferences and contribute to peer-reviewed publications.

Qualifications:

• A Master’s degree in biology, biochemistry, reproductive biology, or a related field.

• Strong background in molecular and cellular biology, with experience in transcriptomics, cell

culture or immunology preferred.

• Proficiency in data analysis and scientific writing.

• Excellent organizational and communication skills.

• A passion for reproductive health and translational research.

Application Process:

Interested candidates should submit the following documents, please note only candidates selected for an

interview will be contacted:

1. A cover letter outlining your research interests and motivation for applying.

2. A detailed CV, including academic qualifications and research experience.

3. Contact information for two academic references.

4. A brief summary of your Master’s thesis.

Application Deadline: March 21st, 2025

Start Date: September 2025

Contact Information:

David A. Landry, PhD

REC Research Laboratory

University of Ottawa, Ottawa

dlandry5@uottawa.ca

University of Ottawa

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