Our Laboratory Animal Resources (LAR) consists of several organisational units providing service to EMBLninvestigators. The Transgenic Service facility currently provides a wide scope of complex techniques to EMBL researchers to

mainly support the generation of genetically modified mice, their import into the facility via embryo transfer and their cryopreservation. As a future direction, the Transgenic Service facility aims to expand the scope to a wider range of organisms investigated by EMBL research groups and to help establishing new frontier organisms accessible for gene editing.

The Transgenic Service directly reports to the Scientific Head of LAR.

Your role

You will be part of a small-scale, high-standard service facility generating genetically modified mouse lines for EMBLresearch groups. You will be expected to organize and conduct all daily procedures related to transgenic and knock-

in/knock-out mouse production.

Tasks Include

Microinjection of DNA (including large constructs), CRISPR/Cas9 approaches, generation of chimera from

targeted ES cells by injection into morula and blastocyst stages.

Organisation and supervision of breeding colonies of wild-type and mutant mice necessary for the work of the

transgenic service under standard operating procedures.

Cryopreservation of mouse stocks (embryo, sperm freezing).
Rederivation of in-coming mouse lines into a SPF barrier facility (IVF, embryo transfer).
Use of intracytoplasmic sperm injection (ICSI).
Maintenance and updating of the online transgenic database for tracking work at the facility.
Establishment and coordination of training activities both internal and external to EMBL in the area of

transgenesis.

You have

As our ideal candidate, you should either be a trained technician or have an equivalent education and experience in working with mice and in the generation of genetically modified mice. An extensive and successful hands-on experience

in techniques such as CRISPR knock-in/transgenesis, pronuclear injection of DNA, ES cell culture and injection and embryo/sperm cryopreservation is essential. Additional experience with genome editing/transgenesis in other organisms is advantageous. You should be able to work both independently and in close collaboration with the scientists and technicians associated with the

transgenic projects. You should be highly motivated and have good communication, project management and organizational skills. English being the working language, good written and spoken command is essential.

You might also have

Knowledge of German is advantageous.

Contract duration: 3 years, renewable up to 9 in total

Salary: Grade 5 or 6; depending on experience and qualifications

Why join us

EMBL is curiosity-driven, community-oriented and international. As an inclusive, equal opportunity employer, we believe that diversity enables us to collaborate more effectively and be innovative in our approaches. We are, therefore, committed to creating an inclusive and flexible culture - one where everyone can realise their full potential and make a positive contribution to our organisation.

We encourage applications from individuals who can complement our existing team – we believe that success is built on having teams whose backgrounds and personal experiences reflect the diversity of the populations that our science serves. We actively encourage applications from all genders and cultures, ethnic groups and all demographics to help us avoid perpetuating biases and oversights at this transformational point in our people strategy.

Enjoy Lots Of Benefits

Financial incentives: Salary free of income tax, Monthly family, child and non-resident allowances, annual salary review, pension scheme, death benefit, long-term care, accident-at-work and unemployment insurances
Flexible working arrangements
Private medical insurance for you and your immediate family (including all prescriptions and generous dental & optical cover)
Generous time off: 30 days annual leave per year, in addition to public holidays
Relocation package including installation grant (if applicable)
Campus life: Free shuttle bus (select sites), on-site library, subsidised on-site gym and cafeteria, casual dress code, extensive sports and social club activities (on campus and remotely)
Family benefits: Kindergarten (Heidelberg), 10 days of child sick leave, generous paid maternity/parental leave and monthly family & child allowances
Benefits for international newcomers: Visa exemption, education grant for private schooling, financial support to travel back to your home country every second year and a monthly non-resident allowance.
For detailed information please visit our employee benefits page here

What else you need to know

International applicants: We recruit internationally and successful candidates are offered visa exemptions. Visit our International Applicants page, to find out more.
EMBL is a signatory of DORA. Find out how we apply DORA principles to our recruitment and performance assessment processes here.
Diversity and inclusion: At EMBL, we strongly believe that inclusive and diverse teams benefit from higher levels of innovation and creative thought. We encourage applications from women, LGBTQ+ & individuals from all nationalities.
How to apply: To apply please submit a cover letter and a CV through our online system. We aim to provide a response within two weeks after the closing date.

Closing Date

06/04/2025

EMBL

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